SOLUBLE HLA IN TYPE I DIABETES. † 543
نویسندگان
چکیده
منابع مشابه
HLA Class I and Genetic Susceptibility to Type 1 Diabetes
OBJECTIVE We report here genotyping data and type 1 diabetes association analyses for HLA class I loci (A, B, and C) on 1,753 multiplex pedigrees from the Type 1 Diabetes Genetics Consortium (T1DGC), a large international collaborative study. RESEARCH DESIGN AND METHODS Complete eight-locus HLA genotyping data were generated. Expected patient class I (HLA-A, -B, and -C) allele frequencies wer...
متن کاملEffect of Soluble HLA Class I Molecule on NK/LAK Cells Activation Induced by Poly I:C
Background: Natural Killer cells express killer inhibitory receptors specific for HLA-class I molecules. These receptors could induce signals that determine NK cells ability to mediate cytotoxicity. Purified soluble form of HLA class I molecules (sHLA) could bind to NK cell receptors and down-regulate the NK killer function. Objective: To evaluate the influence of sHLA and two monoclonal an...
متن کاملSignificant Associations of the rs3104413 Single-nucleotide Polymorphism in the HLA Region with Type 1 Diabetes
Background and Aims: In this study, the effect of rs310441 polymorphism in the human leukocyte antigen (HLA) region on the development of susceptibility or resistance to Type 1 diabetes (T1D) among the people with T1D compared to healthy subjects has been investigated. Materials and Methods: This research, which is based on the examination of 130 cases with T1D and 98 controls, has been carrie...
متن کاملTotal soluble HLA class I and soluble HLA-G in multiple myeloma and monoclonal gammopathy of undetermined significance.
Serum beta2-microglobulin, the light chain of the HLA class I molecular complex, remains one of the best survival prognostic factors in multiple myeloma, but other HLA class I molecules might be of interest in monoclonal gammopathies. In this study, we evaluate total soluble HLA class I (HLA-Is) and soluble HLA-G (HLA-Gs) in 103 patients with newly diagnosed multiple myeloma, 30 patients with m...
متن کاملDecreased levels of serum soluble HLA class I antigens in HLA-B27 positive spondyloarthropathies.
1 Super M, Gillies SD, Foley S, Sastry K, Schweinle JE, Silverman VJ, et al. Distinct and overlapping functions of allelic forms of human mannose binding protein. Nat Genet 1992;2:50–5. 2 Sumiya M, Super M, Tabona P, Levinsky RJ, Arai T, Turner MW, et al. Molecular basis of opsonic defect in immunodeficient children. Lancet 1991;337:1569–70. 3 Garred P, Larsen F, Madsen HO, Koch C. Mannose-bind...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Pediatric Research
سال: 1996
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-199604001-00564